Overview Introduction Antibody dependent cell mediated cytotoxicity (ADCC) is a cooperative response involving login to view 4 more bullets ADCC is an interaction between innate and adaptive immunity that is important because login to view 5 more bullets Activation ADCC is activated by login to view 11 more bullets ADCC is an adaptation of innate immune functions by the adaptive immune system The specificity of ADCC is determined by the specificity of the antibody Effector Mechanisms After recognition of the coated pathogen a variety of cells are recruited to the pathogen ADCC Effector Cells Cell Type Function Mechanism Macrophages General destruction of recognized pathogens Presentation of ingested antigens Release of lytic enzymes and toxic substances Natural killer cells Detection of abnormal cells without MHC expression Anti-tumor cell immunity Release of granzyme and perforin proteins Neutrophils Antibacterial immunity Release of lytic enzymes Generation of reactive oxygen species Eosinophils Antiparasitic immunity Release of major basic protein and other toxic substances