Please confirm topic selection

Are you sure you want to trigger topic in your Anconeus AI algorithm?

Please confirm action

You are done for today with this topic.

Would you like to start learning session with this topic items scheduled for future?

Updated: Aug 22 2019

Transient Hypogammaglobulinemia of Infancy

  • Snapshot
    • An 8-month-old girl is brought to the pediatrician due to several episodes of ear infections and recently developed a cough over the past few months. She has been on several courses of antibiotics. The parents deny a family history of recurrent infections. Laboratory testing is remarkable for low IgG levels, with normal IgA, IgM, and IgE levels.
  • Introduction
    • Transient hypogammaglobulinemia ofinfancy (THI) is the delayed onset of normal immunoglobulins level, usually IgG
    • Pathophysiology
      • normal physiology
        • maternal IgG is slowly catabolized after birth
        • IgG is slowly synthesized in infant
        • IgG reaches physiologic level at 3 - 6 months
      • etiology of THI largely unknown
    • Epidemiology
      • transient hypogammaglobulinemia presents at 5-6 months of age
    • Associated conditions
      • may have increased risk for atopy
        • allergic rhinitis
        • atopic dermatitis
        • food allergies
  • Presentation
    • Symptoms
      • often asymptomatic
      • frequent pyogenic infections
      • frequent sinopulmonary infections
        • otitis media
        • sinusitis
        • upper respiratory infections
    • Physical exam
      • typically no findings
  • Evaluation
    • ↓ IgG
    • May also see ↓ IgA and IgM
  • Differential Diagnosis
    • Bruton's agammaglobulinemia
    • IgA deficiency
    • Common variable immunodeficiency
    • Other primary immunodeficiencies
  • Treatment
    • Antibiotics as needed in symptomatic patients
    • If severe, IVIG
      • can also be considered in those with poor antibody response to vaccines
  • Prevention, Prognosis, and Complications
    • Prognosis
      • very good
      • typically resolves by 2-6 years
    • Complications
      • Severe pyogenic infections
1 of 0
Private Note

Attach Treatment Poll
Treatment poll is required to gain more useful feedback from members.
Please enter Question Text
Please enter at least 2 unique options
Please enter at least 2 unique options
Please enter at least 2 unique options