Snapshot A 2-month-old boy presents with a 2-day history of fever and a painful bump on his rear-end. On exam, there is a fluctuant, erythematous bump with purulent material draining. The abscess is drained and cultured, and the patient is started on antibiotics. The cultures come back positive for S. aureus. This is his second episode of a S. aureus-induced abscess. A nitroblue tetrazolium test is negative. Introduction Chronic granulomatous disease (CGD) is a rare primary immunodeficiency of phagocytes Genetics login to view 2 more bullets Epidemiology login to view 1 more bullet Pathogenesis login to view 6 more bullets Leads to granulomas Presentation Symptoms login to view 8 more bullets Physical exam login to view 3 more bullets Evaluation Flow cytometry reduction of dihydrorhodamine login to view 3 more bullets Nitroblue tetrazolium dye reduction test login to view 1 more bullet Cytochrome c reduction assay login to view 1 more bullet Differential Diagnosis IgA deficiency HIV/AIDs Other primary immunodeficiencies Treatment INF-γ Antibacterial and antifungal prophylaxis Only curative therapy login to view 1 more bullet Prognosis, Prevention, and Complications Prognosis login to view 2 more bullets Prevention login to view 1 more bullet Complications login to view 1 more bullet