Snapshot A 4-year-old African American boy presents to the emergency room for sudden onset severe abdominal pain. He has a history of sickle cell anemia. On physical exam, he is pale, and he has a left upper quadrant palpable mass. Complete blood count is significant for hemoglobin of 7.3 g/dL. Serum unconjugated bilirubin and reticulocyte count are elevated. (Acute splenic sequestration) Introduction Overview login to view 11 more bullets Epidemiology login to view 4 more bullets Pathogenesis login to view 10 more bullets Genetics login to view 5 more bullets Prognosis login to view 2 more bullets Presentation Clinical presentation login to view 27 more bullets Physical exam login to view 4 more bullets Imaging Radiographs login to view 4 more bullets Studies Prenatal testing currently not routinely used Newborn screening login to view 1 more bullet Serum labs login to view 6 more bullets Peripheral blood smear login to view 3 more bullets Differential ß-thalassemia login to view 3 more bullets Treatment Lifestyle login to view 6 more bullets Medical login to view 16 more bullets Surgical login to view 2 more bullets Complications Functional asplenia by an early age login to view 2 more bullets Aplastic crisis associated with parvovirus B19 infection or splenic sequestration crisis login to view 2 more bullets Chronic lung disease and pulmonary hypertention login to view 1 more bullet Renal disease login to view 1 more bullet Retinopathy login to view 1 more bullet Cardiomyopathy login to view 2 more bullets Cholelithiasis login to view 1 more bullet