Overview Snapshot A 3-week-old boy is brought to the pediatrician to undergo a circumcision. Despite the procedure being uncomplicated, the bleeding has not subsided after a few hours. Complete blood count is significant for a platelet count of 85,000/mm3. Peripheral blood smear is shown. Platelet aggregation studies show no response to ristocetin. This was not corrected with the addition of normal plasma. With the addition of ADP, normal aggregation was observed. Introduction Autosomal recessive platelet disorder login to view 1 more bullet Epidemiology login to view 2 more bullets Presentation Symptoms login to view 4 more bullets Evaluation Complete blood cell count login to view 1 more bullet Peripheral smear login to view 1 more bullet Bleeding time login to view 1 more bullet PT and PTT login to view 1 more bullet Platelet aggregation studies login to view 6 more bullets Differential Glanzmann thrombasthenia Idiopathic thrombocytopenic purpura (ITP) von Willebrand disease Treatment Supportive login to view 1 more bullet Surgery of life-threatening bleed login to view 1 more bullet Prognosis, Prevention, and Complications Varying bleeding severity throughout life