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Updated: Feb 12 2018

Sildenafil / Vardenafil

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https://upload.medbullets.com/topic/116068/images/sildenafil mech.jpg
  • Mechanism
    • cGMP phosphodiesterase inhibitor
      • results in less cGMP degradation and ↑ cGMP
    • Drives smooth muscle relaxation in the corpus cavernosum
      • https://upload.medbullets.com/topic/116068/images/sildenafil mech.jpg
        ↑ blood flow to penis
  • Indications
    • Erectile dysfunction
    • Pulmonary hypertension
  • Toxicity
    • Side effects
      • headache
      • flushing
      • dyspepsia
      • impaired blue-green color vision
    • Do not co-administer with nitrates
      • risk of life-threatening hypotension
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