Snapshot A 25-year-old pregnant woman presents to her obstetrician reporting yellow eyes, yellow skin, and dark urine. She reports having a family history of “jaundice,” and some of her relatives have undergone splenectomy. She states she has had periodic jaundice throughout her life, but now that she is pregnant, she is constantly jaundiced. A peripheral smear shows spherocytes. Introduction Overview login to view 2 more bullets Epidemiology login to view 2 more bullets Pathogenesis login to view 3 more bullets Genetics login to view 6 more bullets Presentation History login to view 2 more bullets Symptoms login to view 6 more bullets Physical exam login to view 6 more bullets Studies Osmotic fragility test login to view 1 more bullet Serum labs login to view 4 more bullets Peripheral blood smear login to view 1 more bullet Differential Autoimmune hemolysis login to view 2 more bullets Gilbert syndrome login to view 3 more bullets Treatment Medical login to view 7 more bullets Surgical login to view 5 more bullets Complications Parvovirus B19-induced aplastic crisis Cholecystitis Megaloblastic crisis login to view 1 more bullet