Overview renal amyloidosis Amyloid is misfolded protein that takes the form of a beta-pleated sheet login to view 3 more bullets Diagnosis made by demonstrating login to view 1 more bullet Amyloid can form from a variety of proteins but the above characterisitic are shared properties Amyloid can be localized or systemic Systemic Amyloidosis Affects the entire body and can be of primary or secondary cause Primary login to view 3 more bullets Secondary login to view 4 more bullets Clinical findings login to view 5 more bullets Localized Amyloidosis Affects only a specific organ Localized Amyloidosis Types Protein Derived from Senile cardiac AF Transthyretin Isolated Atrial AANF Atrial Natriuretic Peptide (ANP) Diabetes mellitus type 2 AE Amylin Medullary carcinoma of the thyroid A-CAL Calcitonin Alzheimer's disease β-amyloid Amyloid precursor protein (APP) Dialysis-associated β2-microglobulin MHC class I proteins