Review Question - QID 109775

A 52-year-old African American man presents to his primary care physician with a chief complaint of leg swelling. He says that the swelling began about 2 weeks ago and he cannot recall anything that may have provoked the episode. Otherwise he has had joint pain, headaches, frothy urine, and some tingling in his fingers and toes though he doesn't feel that any of this is related to his swelling. He denies any shortness of breath, back pain, or skull pain. His past medical history is significant for mild rheumatoid arthritis, diabetes, and hypertension all of which are well controlled. Physical exam reveals 3+ pitting edema in his legs bilaterally. A chest radiograph reveals mild enlargement of the cardiac shadow. Urinalysis reveals 3+ protein and casts with a cross appearance under polarized light. A renal biopsy is taken with a characteristic finding seen only under polarized light. Which of the following is associated with the most likely cause of this patient's edema?