Overview Exogenous cell injury resulting in uncontrolled cell degradation normal cellular enzymes responsible for controlled cell death (apoptosis) are inactivated Key principles release of intracellular components presence of inflammation Several types coagulative solid organs which allow preservation of cell shape by coagulation of cell proteins e.g.) heart, liver, kidney liquefactive soft organs which allow lysis of cells and surrounding proteins e.g.) brain caseous presence of fatty cell walled organisms creates a cheese-like consistency e.g.) tuberculosis, fungi fat damage to fat as result of trauma or presence of activated lipase e.g.) pancreas fibrinoid result of protein leaking from vessel wall e.g.) blood vessels gangrenous dry ischemic necrosis without concomitant bacterial infection wet liquefactive necrosis with concomitant bacterial infection