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Updated: May 2 2018

Vitamin K Deficiency

  • Introduction
    • Disruption of all vitamin K-dependent factors
      • II, VII, IX, X, protein C, protein S
    • See Vitamin topic
    • Deficiency most commonly seen in
      • newborns
        • lack gut colonization by bacteria that produce vitamin K
        • newborns are given IM vitamin K shot at birth for prophylaxis
      • malabsorptive conditions
      • long-term antibiotic therapy
        • kills gut bacteria that produce vitamin K
  • Presentation
    • Symptoms
      • hemarthroses
      • intramuscular bleeding
      • GI bleeding
      • excessive bleeding in response to minor trauma
  • Evaluation
    • Labs
      • ↑ PTT, PT
      • normal bleeding time
  • Treatment
    • Administer vitamin K
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