Snapshot A 38-year-old man presents to the emergency department for severe pain in his right foot. He reports that these symptoms are accompanied by fever with the leg turning red. He denies any recent trauma but admits to injecting heroin via his lower extremity since he can no longer do so in his arms. Medical history is significant for opioid-use disorder and hepatitis C infection. On physical exam, tenderness to palpation of the affected area is out of proportion to his superficial skin findings. Introduction Clinical definition login to view 1 more bullet Epidemiology login to view 5 more bullets Etiology login to view 10 more bullets Pathogenesis login to view 6 more bullets Prognosis login to view 1 more bullet Presentation Symptoms login to view 3 more bullets Physical exam login to view 7 more bullets Studies Labs login to view 3 more bullets Intraoperative studies login to view 2 more bullets Diagnostic criteria login to view 2 more bullets Differential Cellulitis Staphylococcus scalded skin syndrome Gas gangrene Treatment Management approach login to view 1 more bullet Medical login to view 4 more bullets Operative login to view 3 more bullets Complications Streptococcal toxic shock syndrome Compartment syndrome Myositis Muscle necrosis