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Overview
  • Mechanism
    • reversible inhibition of H1 histamine receptors
1st generation
  • Drugs
    • diphenhydramine (Benadryl)
    • dimenhydrinate (Dramamine)
    • chlorpheniramine
    • hydroxyzine
    • promethazine
      • abused as a recreational drug ("purple drank" or "sizzurp")
  • Clinical uses
    • allergy
    • motion sickness
    • sleep aid
  • Toxicity
    • antimuscarinic
    • anti-α-adrenergic
    • sedation (lipophilic and thus crosses brain barrier)
2nd generation
  • Drugs
    • loratadine (Claritin)
    • fexofenadine (Allegra)
    • cetirizine (Zyrtec)
    • desloratadine
  • Clinical uses
    • allergy
  • Toxicity
    • decreased entry into CNS (lipophobic) makes this generation far less sedating 
 

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