Snapshot A 4-year-old girl is admitted to the floor with a several day history of bloody diarrhea. Other members of the daycare she attends also had bloody diarrhea. She is irritable and lethargic. Her skin has also turned slightly yellow. Her arms have multiple petechiae. Lab results show creatinine of 4.0 mg/dL, platelet of 40,000/mm3, and hemoglobin of 7 g/dL. A peripheral blood smear shows schistocytes. Introduction Syndrome commonly seen in children login to view 10 more bullets Classic triad login to view 3 more bullets Similar to TTP but without fever and neurologic symptoms Pathogenesis login to view 5 more bullets Epidemiology login to view 5 more bullets Presentation Symptoms login to view 6 more bullets Physical exam login to view 2 more bullets Evaluation Complete blood count login to view 2 more bullets Peripheral smear login to view 1 more bullet ↑ serum creatinine ↑ bleeding time Normal PT/PTT Differential Diagnosis Sepsis TTP DIC Treatment Supportive care with fluids to maintain renal perfusion Prognosis, Prevention, and Complications Prognosis login to view 2 more bullets Prevention login to view 2 more bullets Complications login to view 2 more bullets