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Updated: Apr 21 2021


  • Overview
    • Exogenous cell injury resulting in uncontrolled cell degradation
      • normal cellular enzymes responsible for controlled cell death (apoptosis) are inactivated
    • Key principles
      • release of intracellular components
      • presence of inflammation
    • Several types
      • coagulative
        • solid organs which allow preservation of cell shape by coagulation of cell proteins
          • e.g.) heart, liver, kidney
      • liquefactive
        • soft organs which allow lysis of cells and surrounding proteins
          • e.g.) brain
      • caseous
        • presence of fatty cell walled organisms creates a cheese-like consistency
          • e.g.) tuberculosis, fungi
      • fat
        • damage to fat as result of trauma or presence of activated lipase
          • e.g.) pancreas
      • fibrinoid
        • result of protein leaking from vessel wall
          • e.g.) blood vessels
      • gangrenous
        • dry
          • ischemic necrosis without concomitant bacterial infection
        • wet
          • liquefactive necrosis with concomitant bacterial infection
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