Updated: 4/21/2021

Necrosis

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Overview
  • Exogenous cell injury resulting in uncontrolled cell degradation 
    • normal cellular enzymes responsible for controlled cell death (apoptosis) are inactivated
  • Key principles
    • release of intracellular components
    • presence of inflammation
  • Several types
    • coagulative 
      • solid organs which allow preservation of cell shape by coagulation of cell proteins
        • e.g.) heart, liver, kidney
    • liquefactive 
      • soft organs which allow lysis of cells and surrounding proteins
        • e.g.) brain
    • caseous 
      • presence of fatty cell walled organisms creates a cheese-like consistency
        • e.g.) tuberculosis, fungi
    • fat 
      • damage to fat as result of trauma or presence of activated lipase
        • e.g.) pancreas
    • fibrinoid
      • result of protein leaking from vessel wall 
        • e.g.) blood vessels
    • gangrenous 
      • dry
        • ischemic necrosis without concomitant bacterial infection
      • wet
        • liquefactive necrosis with concomitant bacterial infection                

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