Updated: 7/22/2020

Psammoma Bodies

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Overview
  • psamomma bodiesOnion-skinned and calcified histology
    • represent malignant calcification 
  • Associated with
    • papillary adenocarcinoma of thyroid
    • serous papillary cystadenocarcinoma of the ovary  
    • meningioma
    • mesothelioma 

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Questions (4)
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(M1.PA.17.4751) A 64-year-old female presents to her primary care physician complaining of bloating and early satiety. She also reports that over the past six months, she has developed worsening tiredness that has affected her ability to spend time with her grandchildren. She underwent menopause at the age of 51. Physical examination reveals ascites. A pelvic ultrasound reveals a complex mass arising from the left ovary. A tissue biopsy of the mass is shown in Figure A. Which of the following is the most likely diagnosis?

QID: 108790
FIGURES:
1

Serous cystadenoma

8%

(32/410)

2

Serous cystadenocarcinoma

52%

(214/410)

3

Mucinous cystadenocarcinoma

18%

(75/410)

4

Mature teratoma

4%

(16/410)

5

Granulosa-theca cell tumor

13%

(54/410)

M 2 C

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(M1.PA.13.83) A 37-year-old female visited her primary care physician with a nodular mass in her neck. Fine-needle aspiration of the mass demonstrated malignancy and total thyroidectomy was performed. A histological sample of the excised lesion is shown in Figure A. Which of the following is the most likely diagnosis:

QID: 100384
FIGURES:
1

Lymphoma

2%

(5/212)

2

Follicular carcinoma

17%

(36/212)

3

Medullary carcinoma

21%

(45/212)

4

Papillary carcinoma

53%

(112/212)

5

Undifferentiated malignancy

3%

(7/212)

M 2 E

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