Snapshot A 2-month-old girl presents to the emergency department with lethargy. She was born to a 28-year-old mother at 37 weeks gestation via an uncomplicated spontaneous vaginal delivery. Physical examination is notable for conjunctival pallor and triphalangeal thumbs. Laboratory testing is remarkable for a macrocytic anemia, reticulocytopenia, and elevated erythrocyte adenosine deaminase activity. Introduction Overview login to view 9 more bullets Epidemiology login to view 3 more bullets Pathophysiology login to view 2 more bullets Genetics login to view 4 more bullets Associated conditions login to view 4 more bullets Prognosis login to view 3 more bullets Presentation Symptoms login to view 2 more bullets Physical exam login to view 14 more bullets Studies Serum labs login to view 5 more bullets Invasive studies login to view 3 more bullets Differential Transient erythroblastopenia of childhood login to view 5 more bullets Treatment Medical login to view 8 more bullets Complications Iron overload from blood transfusions Hyperglycemia from corticosteroids Anemia