Overview Common/minor adverse reactions to blood transfusion febrile non-hemolytic transfusion reaction occurs a few hours after a transfusion presents with minor fever/chills caused by host antibody response to donor WBC antigens responds well to NSAIDs (no therapy needed) no hemodynamic abnormalities transfusion-related acute lung injury (TRALI) aka leukoagglutination reaction antibodies in donor blood against receipient white cells occurs 30 minutes after transfusion shortness of breath common transient infiltrates seen on chest radiograph treatment login to view 2 more bullets IgA deficiency anaphylaxis against donor IgA (the patient has no IgA and forms an immune response against it) immediately after receiving transfusion patient experiences login to view 3 more bullets labs login to view 1 more bullet treatment/prevention login to view 1 more bullet minor blood group incompatibility immune reaction to Kell, Lewis, Duffy, or Kidd antigens or Rh incompatibility presents as delayed jaundice, poor increase in hematocrit from transfusion, but otherwise asymptomatic treatment login to view 2 more bullets Serious adverse reactions to blood transfusion ABO incompatibility occurs duringa transfusion acute symptoms of hemolysis (hypotension, tachycardia) other symptoms include back pain, chest pain, dark urine labs login to view 2 more bullets treatment login to view 1 more bullet dilutional pancytopenia infusions of RBCs/fluids dilutes blood cells through plasma expansion and results in pancytopenia Other effects citrate toxicity an anticoagulant used in blood products login to view 2 more bullets may cause hypocalcemia and hypomagnesemia leading to paresthesias hyperkalemia RBC's leak K+ during storage pseudohyperkalemia damage to RBC's from tourniquet placement or a lab phenomena requires no treatment, not genuine hyperkalemia coagulopathy may require transfusion of FFP and platelets