Snapshot A 30-year-old woman presents to the physician's office for evaluation of recurrent fetal losses. She reports having had 3 past spontaneous abortions at <10 weeks of gestational age. She also reports having a history of deep venous thromboses. She denies ever being diagnosed with systemic lupus erythematosus but has been diagnosed with thyroid disease. Physical exam is remarkable for livedo reticularis on her thighs. Further blood testing reveals positive lupus anticoagulant and anticardiolipin antibody. Introduction Clinical definition autoimmune disorder that is often associated with systemic lupus erythematosus (SLE), characterized by thromboses and recurrent spontaneous abortions Epidemiology incidence increases with age demographics female > male affects adults risk factors SLE drugs procainamide isoniazid hydralazine oral contraceptives malignancy Pathogenesis autoantibodies (lupus anticoagulant, anticardiolipin, and anti-β2 glycoprotein antibodies) react against platelet membranes or prothrombin-platelet membrane complex, activating endothelial cells and platelets which further activates complement-mediated thrombosis Associated conditions SLE other autoimmune diseases preeclampsia or eclampsia Prognosis risk of recurrence is high Presentation Symptoms recurrent fetal loss symptoms related to thrombosis site dyspnea abdominal discomfort neurologic symptoms chest pain skin rash Physical exam cutaneous findings include livedo reticularis reticular (lacy) or mottled violaceous rash Studies Labs lupus anticoagulant prolonged dilute Russell viper venom time (DRVVT) test prolonged partial thromboplastin time (PTT) anti-β2 glycoprotein (IgG and IgM) anticardiolipin (IgG and IgM) coagulation studies normal or slightly prolonged prothrombin time normal bleeding time normal platelet count false positives due to antibodies + VDRL/RPR due to anticardiolipin antibodies prolonged PTT due to lupus anticoagulant not corrected by adding normal platelet-free plasma Making the diagnosis based on clinical presentation and laboratory studies diagnostic criteria includes ≥ 1 clinical and ≥ 1 laboratory criteria clinical thrombosis spontaneous abortion at ≥ 10 weeks gestational age premature birth at < 35 weeks gestational age due to eclampsia, pre-eclampsia, or placental insufficiency ≥ 3 spontaneous abortions before < 10 weeks gestational age laboratory lupus anticoagulant anticardiolipin antibody anti-β2 glycoprotein Differential Factor V Leiden mutation distinguishing factor absence of antibodies Antithrombin deficiency distinguishing factor normal PTT Treatment Medical warfarin indications for non-pregnant patients prevention of thrombosis target INR 2-3 aspirin plus unfractionated heparin indications for pregnant patients prevention of pregnancy loss Complications Fetal loss Stroke