Updated: 5/30/2017

Filgrastim / Sargramostim

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Overview
  • Drugs
    • filgrastim
      • granulocyte colony-stimulating factor (G-CSF)
    • sargramostim
      • granulocyte-macrophage colony-stimulating factor (GM-CSF)
  • Mechanism
    • stimulate production and function of neutrophils
    • stimulate other myeloid and megakaryocyte progenitors (sargramostim only)
    • increase concentration of hematopoietic stem cells in the peripheral blood (filgrastim > sargramostim)
  • Clinical use
    • neutropenia
      • cancer chemotherapy
      • aplastic anemia
      • congenital neutropenia
    • stem cell transplantation
  • Toxicity
    • filgrastim
      • minimal
      • bone pain
    • sargramostim
      • fever
      • arthralgias
      • edema
 

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