0%
Topic
Review Topic
0
0
N/A
N/A
Questions
1
0
0
100%
0%
Evidence
1
0
0
Topic
Snapshot
  • A 60-year-old man with a history of human immunodeficiency virus (HIV) presents to his infectious disease doctor for fatigue. He has been on anti-retroviral therapy, including zidovudine. His lab monitoring has shown progressive decrease in his hemoglobin, requiring a blood transfusion once. As his HIV is stable, he does not wish to change his current treatment regimen. He was told there is a medication that would stimulate his bone marrow to produce more red blood cells.
Overview
  • Drugs
    • epoetin alpha
      • recombinant human erythropoietin
        • erythropoietin is physiologically released by the kidney in response to hypoxia
  • Mechanism of action
    • stimulates red blood cell production by the bone marrow via activation of receptors on erythroid progenitor cells
  • Clinical use
    • anemia of renal failure
    • bone marrow suppression
    • chemotherapy-induced anemia
    • drug-induced anemia
  • Adverse effects
    • fever
    • nausea and vomiting
    • rash
    • pruritus
    • increased hematocrit leading to thrombosis
    • hypertension

Please rate topic.

Average 4.5 of 4 Ratings

Questions (1)
Question locked
Sorry, this question is for
PEAK Premium Subscribers only
Upgrade to PEAK
Evidence (1)
EXPERT COMMENTS (4)
Private Note