Updated: 12/31/2016

Nonmegaloblastic Macrocytic Anemia

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Introduction

  • Increase in RBC without megaloblasts present in the bone marrow
  • Associated with accelerated erythropoiesis
  • Caused by
    • liver disease
    • alcoholism
      • folate/B12 may be normal
    • metabolic disorder
      • congenital deficiencies of purine or pyrimidine synthesis
    • hypothyroidism, COPD
    • hemolytic anemia
    • aplastic anemia
    • MDS
  • Reticulocytosis may increase MCV
    • reticulocytes are bigger than mature RBCs 
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