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Updated: 3/10/2022

Pathologic RBC Forms

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  • Overview
    • TypeExampleAssociated Pathology
      Acanthocyte (spur cell)
      • Liver disease, abeta lipoproteinemia
        Basophilic stippling
        • Lead poisoning
          Bite cell
          • G6PD deficiency
            Elliptocyte
            • Hereditary elliptocytosis
              Macro-ovalocyte
              • Megaloblastic anemia, marrow failure
                Ringed sideroblasts
                • Sideroblastic anemia
                  Schistocyte, helmet cell
                  • DIC, TTP/HUS, traumatic hemolysis
                    Schizont
                    • Malaria
                      Sickle cell
                      • Sickle cell anemia
                        Spherocyte
                        • Hereditary spherocytosis, autoimmune hemolysis
                          Teardrop cell
                          • A result of mechanical damage when RBC squeezes through fibrosis to exit bone marrow
                            Target cell
                            • Asplenia, liver disease, thalassemia, HbC disease
                              Heinz bodies
                              • Due to oxidation of hemoglobin sulfahydryl groups to disulfide bonds resulting in hemoglobin precipitation
                              • Splenic macrophages remove precipitated hemoglobin resulting in bite cells
                              • Associated with G6PD
                              Howell-Jolly bodies
                              • Basophilic nuclear remnants found in RBCs associated with functional hyposplenia or asplenia

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                            Hematology | Pathologic RBC Forms
                            • Hematology
                            • - Pathologic RBC Forms

                            11:20 min
                            1/31/2022
                            19 plays
                            5.0
                            (1)
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