Updated: 1/18/2019

Coagulation Cascade

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Overview
 

coagulation

Tests
  • PT (extrinsic pathway)
    • tests function of factors
      • I
      • II
      • V
      • VII 
      • X
    • defect in any of these → ↑ PT
    • best test to follow warfarin therapy
      • normalized as an INR (international normalized ratio)
      • note also increases PTT time
    • also used to measure hepatic function as most of the factor are synthesized in the liver
  • PTT (intrinsic pathway
    • tests function of all factors EXCEPT
      • VII
      • XIII
    • defect in any of these→ ↑ PTT 
      • XII also leads to defect in bradykinin activation
    • best test to follow heparin therapy
      • note also increases PT time
Clinical Importance
  • Hemophilia A/B  
  • Protein C/S deficiency
  • Factor V Leiden
  • Vitamin K deficiency
  • Antithrombin
    • activated by heparin
    • deficiency
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