Introduction A mutation in the prothrombin gene that results in increased expression a point mutation is in the 3' untranslated region (20210A) Resultant state of hypercoagulability via increase in thrombin Presentation Symptoms recurrent DVTs DVTs beginning at a young age Prognosis, Prevention, and Complications Female patients should not use oral contraception, which can increase the hypercoagulable state by increasing coagulation factor synthesis