Updated: 5/19/2019

Coagulation Factor Inhibitor

Review Topic
  • Autoantibody against a coagulation factor
  • Anti-Factor VIII is the most common
    • recall factor VIII is deficient in hemophilia A
  • Symptoms
    • hemarthroses
    • intramuscular bleeding
    • GI bleeding
    • excessive bleeding in response to minor trauma
      • indistinguishable from hemophilia
  • Labs
    • PTT
    • normal PT, bleeding time
  • Mixing studies 
    • supplied factor does not result in clot formation
      • antibody inhibits supplied factors
    • used to distinguish from hemophilia, which would clot when supplied normal plasma

Please rate topic.

Average 5.0 of 5 Ratings

Thank you for rating! Please vote below and help us build the most advanced adaptive learning platform in medicine

The complexity of this topic is appropriate for?
How important is this topic for board examinations?
How important is this topic for clinical practice?
Topic COMMENTS (6)
Private Note