4.8 of 10 Ratings
An 82-year-old male with a history of congestive heart failure presented with new-onset atrial fibrillation. He was initially started on carvedilol, but he now requires an additional agent for rate control. He is started on a medicine and is warned by his physician of the following potential side effects associated with this therapy: nausea, vomiting, confusion, blurry yellow vision, electrolyte abnormalities, and potentially fatal arrhythmia. Which of the following is most likely to increase this patient's susceptibility to the toxic effects associated with this medication?
Elevated AST and ALT
Increased GFR with normal creatinine
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A 58-year-old African-American man with a history of congestive heart failure presents to the emergency room with headache, frequent vomiting, diarrhea, anorexia, and heart palpitations. He is taking a drug that binds the sodium-potassium pump in myocytes. EKG reveals ventricular dysrhythmia. Which of the following is likely also present in the patient?
Changes in color vision
Decreased PR interval
A 55-year-old male presents to the emergency department with dyspnea and palpitations. He does not smoke cigarettes or consume alcohol, and past medical history is insignificant. Blood pressure is 115/75 mmHG and heart rate is 125/min. Heart rhythm is irregularly irregular. After initial treatment with IV digoxin the patient's heart rate drops to 85/min and remains irregular. Which of the following best explains the effect of digoxin in this patient?
Blockade of beta-adrenergic receptors
Calcium channel blockade
Blockade of Na-K-ATPase on cardiac myocytes
Increased ventricular contractility