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Updated: Mar 19 2018

Syphilitic Heart Disease

Images heart.jpg
  • Snapshot
    • A 40-year-old woman presents to her primary care physician for a wellness exam. She currently does not have any acute concerns and reports to feeling well. She has not seen a physician in 20 years but presents today to be tested for sexually transmitted infections at the request of her new partner. She says she may have had a vaginal sore about 17 years ago. She had many sexual partners and infrequently uses condoms. On physical exam, cardiac auscultation is significant for a tambour-like quality S2 heart sound along with a diastolic decrescendo murmur in the left sternal border. A chest radiograph demonstrates calcifications of the ascending aortic arch.
  • Introduction
    • Clinical definition
      • a cardiac complication of tertiary syphilis, where the vasa vasorum becomes impaired
        • this leads to ischemic injury to the aortic media
    • Pathogenesis
      • believed to be caused by a vasculitis (obliterative endarteritis) of the vasa vasorum, which in turn, weakens the aortic root wall, leading to
        • aortic dilation
        • aortic valve regurgitation
  • Imaging
    • Radiography of the chest
      • findings
        • calcification of the ascending aortic arch (usually)
          • this reflects intimal inflammation
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