Introduction Autoregulation is a mechanism that ensures constant blood flow to organs, despite changing resistance (perfusion pressures) in the blood vessels login to view 4 more bullets Hypotheses of Autoregulation Myogenic hypothesis login to view 2 more bullets Metabolic hypothesis login to view 6 more bullets Autoregulation of Organs Organ Factors Determining Autoregulation Heart Local metabolites pO2, adenosine, pCO2, and NO Brain Local metabolites pCO2 andpH Kidneys Myogenic hypothesis tubuloglomerular feedback Lungs Local metabolites pO2→ vasoconstriction Skeletal muscles Local metabolites lactate,K+, and adenosine Skin Sympathetic innervation Organ-Specific Autoregulation Heart login to view 4 more bullets Brain login to view 3 more bullets Kidneys login to view 8 more bullets Lungs login to view 4 more bullets Skeletal muscles login to view 4 more bullets Skin login to view 6 more bullets