Duodenal atresia is a congenital intestinal obstruction that can cause bilious or non bilious vomiting within the first 24 to 38 hours of neonatal life, typically following the first oral feeding. It is associated with in-utero polyhydramnios and is one of the most common causes of fetal bowel obstruction. Antenatal ultrasound can make the diagnosis. If duodenal atresia is not diagnosed antenatally, then the diagnosis can be made radiographically with a plain abdominal x-ray as the first step in evaluation. This may be followed by a controlled contrast exam if needed. Either barium for a limited upper gastrointestinal (UGI) series or water/Pedialyte for an ultrasound evaluation can be performed to confirm the diagnosis. CT plays a limited, if any, role in the evaluation of duodenal atresia.[1]