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Review Question - QID 214892

Pharmacokinetics Bioavailability (F) delayed release formulations will have slower rise and lower peak compared with rapid release formulations QID: 214892 (M1.OMB.1)
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QID 214892 (Type "214892" in App Search)
A 21-year-old man with bipolar disorder is brought to the emergency department by his college roommate after she found him sitting on the couch with an empty bottle of pills and a note saying that he intended to commit suicide. On presentation, he is unable to provide a clear history but his roommate thinks that he had 50 pills left at the time of the overdose. Chart review shows that he usually only takes 1 pill per day to reach a therapeutic range of around 1 mmol/L. About 2 hours after consuming the pills, he undergoes whole bowel irrigation and his plasma levels of lithium are charted as in Figure A. Which of the following best explains why his lithium levels do not increase more dramatically after this overdose?
  • A
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  • A