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Review Question - QID 214736

Antibodies Antibody Structure QID: 214736 (M1.OMB.4869)
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QID 214736 (Type "214736" in App Search)
A 5-year-old boy is being referred for a novel immunodeficiency. Due to persistent bacterial infection, the physician predicts a pathology of humoral immunity. However, serology reveals normal B-cell counts and antibody titers for all isotypes. Using immunolabeling techniques, bacteria are found to be coated with the patient’s antibodies, but macrophages do not engage in phagocytosis. Additionally, immunolabeled C1 complexes do not colocalize with antibodies. Pathophysiology of this patient’s conditions is most likely due to dysfunction of which of the following?
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