Review Question - QID 214517

A 34-year-old African American man is brought to the emergency department with a 1-hour history of increasing shortness of breath. He says that he was smoking outside during a break at work when he started having difficulty breathing. He has smoked 2 packs of cigarettes per day since he was 14 years old and has a childhood history of asthma. He works as a contractor and primarily replaces walls in old houses. His family history is significant for autoimmune diseases as well as lung cancer. Histology reveals the findings shown in Figure A. Which of the following is the most likely cause of this patient's symptoms?