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Review Question - QID 214347

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QID 214347 (Type "214347" in App Search)
A 37-year-old man presents to a primary care physician to establish care. He feels overall healthy, but has noticed increasing fatigue with exercise. He has no past medical history, is currently taking no medications, and has no allergies. His family history is significant for 2 uncles that died in their 40's from myocardial infarctions and he has a brother with diagnosed coronary artery disease. Lab analysis is as follows:

Serum:
Na+: 139 mEq/L
K+: 4.1 mEq/L
Cl-: 101 mEq/L
Ca2+: 8.5 mg/dL
Total cholesterol: 195 mg/dL (Normal: < 200 mg/dL)
Triglycerides: 1012 mg/dL (Normal: < 150 mg/dL)

A drug with which of the following mechanisms of action would be the most appropriate therapy?