Review Question - QID 213781

A 75-year-old white man presents to his cardiologist with a 2 week history of increasing dyspnea. He has been experiencing increasing shortness of breath while doing activities of daily living and has occasionally had shortness of breath even at rest. Physical exam reveals rales and coarse crackles at the bases of the lungs bilaterally. Based on worsening symptoms, his medications are changed to lisinopril, metoprolol, chlorthalidone, spironolactone, and digoxin as needed for symptoms. Which of these medications have been shown to improve survival in this patient?