Review Question - QID 213716

A 52-year-old man presents to his primary care physician with a 1-month history of increasing abdominal distension. He says he noticed that his abdomen was getting bigger and that he was gaining a lot of weight. His past medical history is significant for schizophrenia and periods of homelessness. On presentation, he is found to have a distended abdomen with hepatomegaly. He is also found to have increased jugular venous pressure and bruises over his arms and legs. Labs are notable for an INR of 1.9. He is given a medication and told that side effects include hyponatremia, hypokalemia, and hypocalcemia. Which of the following segments of the nephron is most likely targeted by this drug?