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Review Question - QID 213570

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QID 213570 (Type "213570" in App Search)
A 6-year-old boy presents to a pediatrician for initial evaluation. He was recently adopted from abroad and his parents want to establish care in the United States. His medical history is unclear and there are no records on any family history. On presentation, he is found to fall below the 5th percentile in height for his age with shortened 4th and 5th digits. Physical exam reveals wrist spasms when his blood pressure is taken. Radiographs reveal decreased bone mineral density and several healing fractures. Which of the following mechanisms is most likely associated with this patient's presentation?