Review Question - QID 212606

A 25-year-old woman presents to her primary care physician with 3 weeks of palpitations and shortness of breath while exercising. She says that these symptoms have been limiting her ability to play recreational sports with her friends. Her past medical history is significant for pharyngitis treated with antibiotics and her family history reveals a grandfather who needed aortic valve replacements early due to an anatomic abnormality. She admits to illicit drug use in college, but says that she stopped using drugs 4 years ago. Physical exam reveals a clicking sound best heard in the left 6th intercostal space. This sound occurs between S1 and S2 and is followed by a flow murmur. Which of the following is most likely associated with the cause of this patient's disorder?