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Review Question - QID 212443

Osteogenesis Imperfecta / Brittle Bone Disease Introduction Pathogenesis QID: 212443 (M1.OMB.18.4696)
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QID 212443 (Type "212443" in App Search)
A 5-year-old girl accompanied by her mother presents to the emergency department after suffering a fall on the elementary school playground. Her mother reports that a child on the playground pushed her daughter who fell on her right side, after which she screamed and was found clutching her right leg. The girl's past medical history is significant for a fracture of the left femur and right radius over the past 2 years and an auditory deficit requiring hearing aid use starting 6 months ago. Inspection reveals a relatively short girl in moderate distress. She has brown opalescent teeth. She refuses to bear weight on her right lower extremity. Radiography of the right lower extremity reveals a femoral midshaft fracture. Which of the following is the most likely etiology of the patient's condition?
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