Review Question - QID 212343

A 47-year-old woman presents to the physician with complaints of fatigue accompanied by symmetric pain, swelling, and stiffness in her wrists, fingers, knees, and other joints. She describes the stiffness as being particularly severe upon awakening, but gradually improves as she moves throughout her day. Her physician initially suggests that she take NSAIDs. However, after a few months of minimal symptomatic improvement, she is prescribed an immunosuppressive drug that prevents IL-2 transcription by preventing the activation of nuclear factor of activated T-cells (NFAT). What is the main toxicity that the patient must be aware of with this particular class of drugs?