Review Question - QID 211094

A 17-year-old girl presents to her dermatologist for treatment of severe acne vulgaris pictured in Figure A. She has tried multiple topical and oral treatments but has been unsatisfied with the results. She reports feeling self conscious about her appearance, and would like to resolve her acne before she begins her undergraduate studies in the fall. One of her friends recently completed a course of oral isotretinoin for acne vulgaris, and she asks if she would be a candidate for the therapy. The risks and benefits of the treatment are reviewed with the patient, and an in-office urine pregnancy test is negative. Isotretinoin is commenced. Which of the following is a potential consequence of this treatment?