Review Question - QID 211010

A 17-year-old girl is brought to the emergency department by her father with fever, chills, and a body rash. Her father reports that 3 days ago, his daughter underwent surgery for a deviated nasal septum. Since then, she has been "sleepy" and in moderate pain. When the patient’s father came home from work today, he found the patient on the couch, shivering and complaining of muscle aches. He also noticed a rash all over her body. The patient says she feels “hot and cold” and also complains of lightheadedness. The patient has no other past medical history. She has been taking oxycodone for the post-surgical pain. She denies any recent travel. The father reports the patient’s brother had a minor “cold” last week. The patient’s mother has major depressive disorder. The patient denies tobacco or illicit drug use. She says she has tried beer before at parties. Her temperature is 103.2°F (39.6°C), blood pressure is 84/53, pulse is 115/min, respirations are 12/min, and oxygen saturation is 99% on room air. The patient is awake and oriented but slow to respond. There is no focal weakness or nuchal rigidity. Physical examination reveals nasal packing in both nostrils, tachycardia, and a diffuse, pink, macular rash that is also present on the palms and soles. Initial labs show a neutrophil-dominant elevation in leukocytes, a creatinine of 2.1 mg/dL, an aspartate aminotransferase of 82 U/L, and an alanine aminotransferase of 89 U/L. Which of the following is the most likely cause of the patient’s symptoms?