Review Question - QID 210680

A 52-year-old woman presents to her primary care physician because she has been feeling pain in her right leg. Specifically, she says that an area on her right thigh has been feeling tender and swollen over the past few weeks. Her past medical history is significant for obesity, poorly controlled diabetes, and hypertension. She also has been taking estrogen replacement therapy and drinking alcohol to cope with her symptoms of menopause. Her family history is significant for cardiomyopathy. On physical exam, there is erythema and edema along a cord-like lesion in her thigh. This lesion feels thick and hardened on palpation and is tender to the touch. She is started on compression therapy as well as NSAIDs for pain management. Which of the following characteristics of this patient most likely increased her risk for this disorder?