Review Question - QID 110025

A 62-year-old woman presents to her primary care provider with anal bleeding. She reports a 4-month history of intermittent anal bleeding that was initially mild but has increased in severity over the past 2 weeks. She also reports having intermittent mucoid discharge from her anus. She denies any pain with defecation but does experience occasional constipation that has been increasing in frequency over the past month. Her past medical history is notable for hypertension and breast cancer status-post-mastectomy and radiation therapy. She takes enalapril. She has a 15-pack-year smoking history and drinks 3-4 glasses of wine per week. Her temperature is 98.4°F (36.9°C), blood pressure is 135/85 mmHg, pulse is 85/min, and respirations are 18/min. On exam, she appears pale but is pleasant and conversational. Digital rectal examination reveals a small mass within the anal canal. Anoscopy demonstrates an erythematous irregular mass arising from the mucosa proximal to the dentate line. Which of the following histologic findings is most likely to be seen in this patient’s lesion?