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Review Question - QID 109641

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QID 109641 (Type "109641" in App Search)
A 61-year-old male presents to the emergency room with difficulty breathing. He has had a dry cough and shortness of breath for the last 6 days. This morning, his cough acutely worsened prompting him to seek care. His temperature is 99.0°F (37.2°C), blood pressure is 140/85 mmHg, pulse is 110/min, respirations are 27/min, and pulse oximetry is 88% on room air. There are decreased breath sounds at the right lung base. Chest radiograph is shown in Figure A. You perform a thoracentesis and pleural fluid findings are shown below:

Appearance: Clear
Lactate dehydrogenase: 40 U/L
Specific gravity: 1.01
Leukocyte count: 200/mm^3
Erythrocyte count: Trace
Gram stain: Negative

Which of the following is the most likely underlying etiology for this patient’s respiratory distress?
  • A

Tuberculosis

22%

34/155

Cirrhosis

37%

58/155

Pancreatitis

9%

14/155

Chylothorax

20%

31/155

Nephritic syndrome

6%

9/155

  • A

Select Answer to see Preferred Response

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This patient has a right-sided pleural effusion with thoracentesis results consistent with a transudative process such as cirrhosis.

Transudative pleural effusions are caused by increased hydrostatic pressure or decreased oncotic pressure in blood vessels. Findings include clear fluid with low protein content, low LDH, and specific gravity less than 1.012. Etiologies include cirrhosis, congestive heart failure, and nephrotic syndrome.

Figure/Illustration A is a chest radiograph with evidence of right-sided pleural effusion (yellow arrow). Note, on the left side, there is a sharp costophrenic angle (red arrow) that is present when there is no pleural effusion.

Incorrect Answers:
Answer 1: Tuberculosis would lead to an exudative pleural effusion that is characterized by cellular, protein rich fluid with a specific gravity greater than 1.012.

Answer 3: Pancreatitis and other abdominal disorders lead to an exudative pleural effusion.

Answer 4: Chylothorax occurs most commonly in the setting of trauma to the thoracic duct and would present with an exudative pleural effusion with a milky appearance and increased triglycerides.

Answer 5: Nephritic syndrome does not commonly cause effusions. However, nephrotic syndrome is associated with a transudative pleural effusion.

Bullet Summary:
A transudative pleural effusion presents on thoracentesis with findings of clear fluid with low protein content, low LDH, and specific gravity less than 1.012.

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