Select a Community
Are you sure you want to trigger topic in your Anconeus AI algorithm?
You are done for today with this topic.
Would you like to start learning session with this topic items scheduled for future?
II
9%
22/233
V
14%
33/233
VII
55%
128/233
IX
4%
9/233
X
13%
31/233
Select Answer to see Preferred Response
This patient is being treated with warfarin due to a recent pulmonary embolism. Factor VII is the first factor involved in the extrinsic pathway of the coagulation cascade. Warfarin inhibits the factors in the extrinsic pathway of the coagulation cascade. The extrinsic factors include II, VII, IX, and X. The initial factor activated is factor VII, which binds to tissue factor released by damaged tissue. The first factors that warfarin inhibits are protein C and factor VII. Heparin is used in addition to warfarin for the first few days of treatment due to the transient hypercoagulable state that occurs as a result of the shorter half-life of protein C and protein S. Patients with warfarin will have an elevated PT with normal PTT and bleeding time. Incorrect Answers: Answer 1: Factor II, prothrombin, is cleaved to thrombin following activation of factor V. It is inhibited by warfarin. Answer 2: Factor V is not affected by warfarin. Answer 4: Factor IX deficiency is seen in hemophilia B. It is also part of the intrinsic pathway inhibited by warfarin but is not the initial factor. Answer 5: Factor X is part of the extrinsic pathway but is not the initial factor of the pathway. Bullet Summary: Factor VII is the initial factor activated in the extrinsic coagulation cascade.
2.1
(10)
Please Login to add comment