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Dengue virus
25%
63/256
Lymphocytic choriomeningitis virus
6%
15/256
Lassa fever virus
9%
22/256
Hantavirus
23/256
Marburg virus
39%
101/256
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The patient in this vignette presents with hemorrhagic fever and laboratory findings suggestive of Ebola virus. Ebola virus and Marburg virus are members of the filoviridae family and are characterized by filamentous virions of varying lengths with (-) ssRNA. Ebola virus is one of many viruses known to cause hemorrhagic fever. Ebola typically presents 2-21 days after exposure. Symptoms initially include headache, fever, and fatigue but rapidly progress to high fever, hematemesis, and altered mental status. Like Marburg virus, it is a enveloped, linear (-) ssRNA virus with a helical capsid. These viruses are part of the filoviridae family, named because of the filamentous shape of individual virions. Incorrect Answers: Answer 1: Dengue virus is an enveloped, icosahedral (+) ssRNA virus of the flavivirus family that is known to cause a painful fever (“break bone fever”) and/or hemorrhagic shock. Answers 2-3: Lymphocytic choriomeningitis virus (LCMV) and Lassa fever virus are members of the arenaviridae family. These are circular (-) ssRNA viruses that cause hemorrhagic fever and meningitis, respectively. Answer 4: Hantavirus is a circular (-) ssRNA virus of the bunyaviridae family. It primarily causes a deadly pulmonary syndrome. Bullet Summary: Ebola virus and Marburg virus are linear (-) ssRNA viruses from the filovirus family.
2.5
(11)
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