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Cellular swelling
84%
326/389
Mitochondrial vacuolization
3%
10/389
Nuclear pyknosis
5%
18/389
Plasma membrane damage
0%
1/389
Fragmented cells and debris
Select Answer to see Preferred Response
This patient most likely had an arterial thrombectomy after which her myocytes were reperfused. Cellular swelling is a microscopic pathological finding that indicates that cell injury is likely reversible. Microscopically, changes in cells with reversible damage include decreased glycogen stores, fatty change, membrane blebbing, nuclear chromatin clumping, and cellular/mitochondrial swelling due to decreased Na/K pump activity. These changes can be reversed with prompt oxygen delivery (reperfusion). Of note, these cells may have irreversible injury and cell death from reperfusion injury if they were deprived of oxygen for too long. Incorrect Answers: Answer 2: Mitochondrial vacuolization indicates irreversible cell injury. Answer 3: Nuclear pyknosis or condensation indicates irreversible cell injury. Answer 4: Plasma membrane damage indicates irreversible cell injury. Answer 5: Fragmented cells and debris are seen microscopically with caseous necrosis which is a form of irreversible cell damage. Bullet Summary: Reversible cell injury can be reversed by oxygen delivery, is characterized by decreased ATP synthesis, and decreased Na/K pump activity leading to cellular swelling and ribosomal detachment.
3.6
(5)
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