Select a Community
Are you sure you want to trigger topic in your Anconeus AI algorithm?
You are done for today with this topic.
Would you like to start learning session with this topic items scheduled for future?
Azithromycin
11%
10/95
Amoxicillin-clavulanate
8%
8/95
Intranasal beclomethasone
2%
2/95
Amoxicillin
Amphotericin
65%
62/95
Select Answer to see Preferred Response
The patient in this vignette presents with headache, facial pain, and a necrotic black eschar suggestive of mucormycosis. The first-line treatment for mucormycosis is amphotericin. Mucormycosis refers to several different similar diseases caused by invasive non-septate filamentous fungi of the Mucor order. They are characterized histologically by branches at 90 degree angles. Mucormycosis frequently causes severe rhinocerebral infections in immunocompromised patients with poorly controlled diabetes or hematologic malignancies. Amphotericin is the first-line treatment for patients with mucormycosis. The maxillary sinus is most often affected in adults while the ethmoid sinus is most often affected in children. Figure A demonstrates a classic mucormycosis lesion. Note the well-defined necrotic eschar overlying the right maxillary region. Illustration A demonstrates the characteristic appearance of mucormycosis on histology. Note the irregular non-septate hyphae that branch at approximately 90-degree angles. Incorrect Answers: Answer 1: Azithromycin is a macrolide antibiotic that serves as an alternative to amoxicillin in the treatment of severe cases of bacterial sinusitis caused by S. pneumoniae and H. influenzae. Answer 2: Amoxicillin-clavulanate contains a beta-lactamase inhibitor for bacterial strains that produce beta-lactamase which can break down antibiotics like penicillin and amoxicillin. M. catarrhalis is a common cause of bacterial sinusitis that produces beta-lactamase leading to resistance to amoxicillin. The recommended agents for use against M. catarrhalis include amoxicillin-clavulanate, second- and third-generation cephalosporins, and trimethoprim-sulfamethoxazole. Answer 3: Intranasal beclomethasone is used as an adjunctive therapy in patients with acute rhinosinusitis to provide symptomatic relief in patients with milder symptoms. Answer 4: Amoxicillin is a beta-lactam antibiotic that is used as a first-line therapy for severe cases of bacterial sinusitis caused by S. pneumoniae and H. influenzae. Bullet Summary: Mucormycosis is a life-threatening form of sinusitis affecting immunocompromised individuals that should be treated with amphotericin as a first-line therapy.
3.3
(3)
Please Login to add comment