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Review Question - QID 107097

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QID 107097 (Type "107097" in App Search)
A 17-year-old male is diagnosed with acne vulgaris during a visit to a dermatologist. He is prescribed a therapy that is a derivative of vitamin A. He has no other significant past medical history. Which of the following is the major side effect of this therapy?

Hyperglycemia

11%

14/126

Hyperlipidemia

35%

44/126

Fatigue

4%

5/126

Xerophthalmia

29%

36/126

Alopecia

17%

22/126

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This patient was most likely given isotretinoin for acne treatment, a vitamin A derivative. The chief side effects of isotretinoin are hypertriglyceridemia and teratogenicity.

Isotretinoin is used to treat severe nodular acne in children and adults. Major side effects of isotretinoin include hypertriglyceridemia and teratogenicity. Female patients who start isotretinoin are required to have a negative pregnancy test prior to starting therapy and are required to have appropriate birth control as well as regular pregnancy tests while on therapy to prevent accidental pregnancy, under the iPLEDGE program.

Incorrect Answers:
Answers 1 & 3-5: These are not the major side effects of isotretinoin. Though fatigue is a side effect of isotretinoin, the major side effects are hypertriglyceridemia and teratogenicity. Alopecia can be seen in both vitamin A deficiency or excess. Xerophthalmia is a symptom of vitamin A deficiency.

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